MUTYH Antibody

Catalog Number:

31101

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q13232
Gene ID:4832

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a C terminal 300 amino acids of human mutY homolog (E. coli)

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total MUTYH protein.

Applications:

ELISA WB IHC

Background:

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

Predicted MW: 60kd
ELISA: 1:2000-1:10000
Western blotting: 1:1000-1:5000
Immunohistochemistry: 1:50-1:200

Datasheet PDF