PLC gamma 1 Antibody

Catalog Number:

29227

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P19174

Form of Antibody:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt

Storage/Stability:

Immunogen:

A synthesized peptide derived from human PLCG1

Purification:

Immunogen affinity purified

Specificity/Sensitivity:

PLCG1 Antibody detects endogenous levels of total PLCG1

Applications:

WB IHC

Background:

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

WB 1:500-1:2000 

Datasheet PDF