Product Datasheet  
PLC gamma 1 Antibody  
Catalog Number: 29227  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P19174
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
  • Storage：  
  • Store at -20°C/1 year
  • Immunogen：  
  • A synthesized peptide derived from human PLCG1
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • WB 1:500-1:2000 

    • other_names：  
    • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1, EC 3.1.4.11, PLC-148, PLC-II, PLC-gamma1, PLC1, PLCG-1, Phospholipase C-gamma-1
    • Purification：  
    • Immunogen affinity purified
    • Specificity：  
    • PLCG1 Antibody detects endogenous levels of total PLCG1
    • Applications：  
    • WB IHC
    • Background：  

    • The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.




 
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