JMJD3 Antibody

Catalog Number:

25412

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O15054
Gene ID:23135

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide from near the amino terminus of human JMJD3.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This antibody is specific for JMJD3 and will not recognize other JMJD proteins.

Applications:

ELISA WB

Background:

The Jumonji domain-containing protein 3 (JMJD3) functions as a trimethylation-specific demethylase, converting the trimethylated histone H3 Lys27 residue to the dimethylated form, and is thought to also function as a transcriptional repressor. JMJD3 plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. JMJD3 can also interact with and demethylate p53, resulting in its stabilization and localization to the nucleus in mouse embryo fibroblasts during neural stem cell differentiation.

References:

appl_detail:

Datasheet PDF