Product Datasheet  
JMJD3 Antibody  
Catalog Number: 25412  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:O15054
    Gene ID:23135
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 16 amino acid peptide from near the amino terminus of human JMJD3.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Jumonji domain-containing protein 3, Lysine-specific demethylase 6B, KDM6B
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • This antibody is specific for JMJD3 and will not recognize other JMJD proteins.
  • Applications：  
  • ELISA WB
  • Background：  
  • The Jumonji domain-containing protein 3 (JMJD3) functions as a trimethylation-specific demethylase, converting the trimethylated histone H3 Lys27 residue to the dimethylated form, and is thought to also function as a transcriptional repressor. JMJD3 plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. JMJD3 can also interact with and demethylate p53, resulting in its stabilization and localization to the nucleus in mouse embryo fibroblasts during neural stem cell differentiation.



 
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