AXIN2 Antibody

Catalog Number:

25253

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9Y2T1
Gene ID:8313

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 20 amino acid peptide near the carboxy terminus of human AXIN2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

AXIN2 antibody is predicted to not cross-react with AXIN2. At least four isoforms of AXIN2 are known to exist; this antibody will recognize all four.

Applications:

ELISA WB IHC

Background:

Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

References:

appl_detail:

Datasheet PDF