Product Datasheet  
AXIN2 Antibody  
Catalog Number: 25253  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9Y2T1
    Gene ID:8313
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 20 amino acid peptide near the carboxy terminus of human AXIN2.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • AXIL, AXI1, conductin
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • AXIN2 antibody is predicted to not cross-react with AXIN2. At least four isoforms of AXIN2 are known to exist; this antibody will recognize all four.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.



 
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