TREX2 Antibody

Catalog Number:

24816

Amount:

100μg

Price:

$319

Swiss-Prot No:

Q9BQ50

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 15 amino acid peptide near the carboxy terminus of human TREX2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This TREX2 antibody will not cross-react with the related protein TREX1.

Applications:

ELISA WB IHC

Background:

TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.

References:

appl_detail:

Datasheet PDF