Product Datasheet  
TREX2 Antibody  
Catalog Number: 24816  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Q9BQ50
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 15 amino acid peptide near the carboxy terminus of human TREX2.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Three prime repair exonuclease 2
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • This TREX2 antibody will not cross-react with the related protein TREX1.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.



 
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