Spred2 Antibody

Catalog Number:

24774

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q7Z698
Gene ID:200734

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 13 amino acid peptide near the center of the human Spred2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This Spred2 antibody is predicted to have no cross-reactivity to Spred1 or Spred3.

Applications:

ELISA WB

Background:

Spred2 is a member of the Sprouty family, a group of proteins that act as negative regulators during development. Like Spred1, Spred2 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. At least two isoforms of Spred2 are known to exist.

References:

appl_detail:

Datasheet PDF