Product Datasheet  
Spred2 Antibody  
Catalog Number: 24774  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q7Z698
    Gene ID:200734
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 13 amino acid peptide near the center of the human Spred2.
  • reactivity：  
  • Hu
  • appl_detail：  
  • other_names：  
  • Sprouty-related EVH1 domain-containing protein 2
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • This Spred2 antibody is predicted to have no cross-reactivity to Spred1 or Spred3.
  • Applications：  
  • ELISA WB
  • Background：  
  • Spred2 is a member of the Sprouty family, a group of proteins that act as negative regulators during development. Like Spred1, Spred2 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. At least two isoforms of Spred2 are known to exist.



 
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