CDNF Antibody

Catalog Number:

24582

Amount:

100μg

Price:

$319

Swiss-Prot No:

Q49AH0

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 9 amino acid peptide from near the carboxy terminus of human CDNF.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This antibody does not cross-react with MANF.

Applications:

ELISA WB IHC

Background:

The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson’s disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson’s disease. At least two isoforms of CDNF are known to exist.

References:

appl_detail:

Datasheet PDF