Product Datasheet  
CDNF Antibody  
Catalog Number: 24582  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Q49AH0
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 9 amino acid peptide from near the carboxy terminus of human CDNF.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Conserved dopamine neurotrophic factor, arginine-rich, mutated in early stage tumors-like 1, ARMET-like 1, ARMETL1
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • This antibody does not cross-react with MANF.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson’s disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson’s disease. At least two isoforms of CDNF are known to exist.



 
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