TDP43 Antibody

Catalog Number:

24557

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q13148
Gene ID:23435

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 18 amino acid peptide from near the center of human TDP43.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least two isoforms are known to exist for this protein; this TDP43 antibody only recongizes the longer of the two isoforms.

Applications:

ELISA WB ICC

Background:

TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3�?splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.

References:

appl_detail:

Datasheet PDF