Product Datasheet  
TDP43 Antibody  
Catalog Number: 24557  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q13148
    Gene ID:23435
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 18 amino acid peptide from near the center of human TDP43.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • TAR DNA binding protein, TARDBP
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • At least two isoforms are known to exist for this protein; this TDP43 antibody only recongizes the longer of the two isoforms.
  • Applications：  
  • ELISA WB ICC
  • Background：  
  • TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3�?splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.



 
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