IL-1RAcP Antibody

Catalog Number:

24068

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9NPH3
Gene ID:3556

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids near the carboxy terminus of IL-1RAcP, which differs from. The sequence of mouse origin by three amino acids.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

It has no cross activity to other member in the IL-1 receptor family.

Applications:

ELISA WB ICC

Background:

The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I(IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-κB inducing kinae (NIK) and of NF-κB, recruites to the IL-1R complex through IL-1 RAcP. IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP. Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.

References:

appl_detail:

Predicted MW: 66 kd

Datasheet PDF