Product Datasheet  
IL-1RAcP Antibody  
Catalog Number: 24068  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9NPH3
    Gene ID:3556
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a peptide corresponding to amino acids near the carboxy terminus of IL-1RAcP, which differs from. The sequence of mouse origin by three amino acids.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 66 kd
  • other_names：  
  • IL-1RAcP
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • It has no cross activity to other member in the IL-1 receptor family.
  • Applications：  
  • ELISA WB ICC
  • Background：  
  • The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I(IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-κB inducing kinae (NIK) and of NF-κB, recruites to the IL-1R complex through IL-1 RAcP. IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP. Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.



 
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