FHL2 Antibody

Catalog Number:

21692

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q14192 NCBI Protein: NP_001034581.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.16~28 (I-L-R-E-E) derived from Human FHL2.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total FHL2 protein.

Applications:

WB

Background:

 May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. 

Genini M., Schwalbe P., Scholl F.A., Remppis A., Mattei M.-G., Schaefer B.W.DNA Cell Biol. 16:433-442(1997)

Tanahashi H., Tabira T.Hum. Mol. Genet. 9:2281-2289(2000)

References:

appl_detail:

 Western blotting: 1:500�?:1000

Datasheet PDF