C/EBPb Antibody

Catalog Number:

21675

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P17676
NCBI Protein: NP_005185.2

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.336~340(E-P-L-L-A) derived from Human C/EBPb.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous levels of total C/EBPb protein.

Applications:

WB

Background:

Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation

Buck M., Poli V., Hunter T., Chojkier M. Mol. Cell 8:807-816(2001)
Gauci S., Helbig A.O., Slijper M., Krijgsveld J. Mohammed S.Anal. Chem. 81:4493-4501(2009)

References:

appl_detail:

Predicted MW: 36kd
Western blotting: 1:500~1:1000

Datasheet PDF