Oct-1 Antibody

Catalog Number:

21674

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P14859
NCBI Protein: NP_001185712.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.270~274(T-P-K-R-I) derived from Human Oct-1.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Oct-1 protein.

Applications:

WB IF

Background:

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR By similarity. In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.

Prefontaine G.G., Walther R., Giffin W. J. Biol. Chem. 274:26713-26719(1999)
Mahajan S.S., Wilson A.C. Mol. Cell. Biol. 20:919-928(2000)

References:

appl_detail:

Predicted MW: 90kd
Western blotting: 1:500~1:1000

Immunofluorescence�?:100~1:200

 

Datasheet PDF