Product Datasheet  
Oct-1 Antibody  
Catalog Number: 21674  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P14859
    NCBI Protein: NP_001185712.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20�?for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.270~274(T-P-K-R-I) derived from Human Oct-1.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Predicted MW: 90kd
    Western blotting: 1:500~1:1000
    Immunofluorescence�?:100~1:200
     
  • other_names：  
  • 1-Oct; OTF1; oct-1B
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous levels of total Oct-1 protein.
  • Applications：  
  • WB IF
  • Background：  

  • Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR By similarity. In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.

    Prefontaine G.G., Walther R., Giffin W. J. Biol. Chem. 274:26713-26719(1999)
    Mahajan S.S., Wilson A.C. Mol. Cell. Biol. 20:919-928(2000)




 
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