CUEDC2 Antibody

Catalog Number:

21673

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9H467
NCBI Protein: NP_076945.2

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.262~266(D-V-R-N-P) derived from Human CUEDC2.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total CUEDC2 protein.

Applications:

WB

Background:

Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.

Zhang P.-J., Zhao J., Li H.-Y. EMBO J. 26:1831-1842(2007)

References:

appl_detail:

Predicted MW: 32kd
Western blotting: 1:500~1:1000
 

Datasheet PDF