CCR5(CD195) Antibody

Catalog Number:

21666

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P51681
NCBI Protein: NP_000570.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.11~15(D-I-N-Y-Y) derived from Human CCR5(CD195).

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total CCR5(CD195) protein.

Applications:

WB

Background:

Receptor for a number of inflammatory CC-chemokines including MIP-1-a, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

Samson M., Labbe O., Mollereau C. Biochemistry 35:3362-3367(1996)
Raport C.J., Gosling J., Schweichart V.L. J. Biol. Chem. 271:17161-17166(1996)
Combadiere C., Ahuja S.K., Tiffany H.L., Murphy P.M.J. Leukoc. Biol. 60:147-152(1996)

References:

appl_detail:

Predicted MW: 41kd
Western blotting: 1:500~1:1000

Datasheet PDF