Product Datasheet  
CCR5(CD195) Antibody  
Catalog Number: 21666  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P51681
    NCBI Protein: NP_000570.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.11~15(D-I-N-Y-Y) derived from Human CCR5(CD195).
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Predicted MW: 41kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • CKR5; CD195; CKR-5
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total CCR5(CD195) protein.
  • Applications：  
  • WB
  • Background：  
  • Receptor for a number of inflammatory CC-chemokines including MIP-1-a, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

    Samson M., Labbe O., Mollereau C. Biochemistry 35:3362-3367(1996)
    Raport C.J., Gosling J., Schweichart V.L. J. Biol. Chem. 271:17161-17166(1996)
    Combadiere C., Ahuja S.K., Tiffany H.L., Murphy P.M.J. Leukoc. Biol. 60:147-152(1996)



 
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