DP-1 Antibody

Catalog Number:

21654

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q14186
NCBI Protein: NP_009042.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.13~17(E-L-K-V-F) derived from Human DP-1

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous levels of total DP-1 protein.

Applications:

WB

Background:

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis.

Wu C.-L., Zukerberg L.R., Ngwu C., Harlow E., Lees J.A.Mol. Cell. Biol. 15:2536-2546(1995)

References:

appl_detail:

Predicted MW: 45kd
Western blotting: 1:500~1:1000
 

Datasheet PDF