ASH2L Antibody

Catalog Number:

21497

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9UBL3
NCBI Protein: NP_004665.2

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.620~624(G-R-R-S-P) derived from Human ASH2L.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total ASH2L protein.

Applications:

WB

Background:

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.

Wysocka J., Myers M.P., Laherty C.D., Eisenman R.N., Herr W.Genes Dev. 17:896-911(2003)
Patel A., Dharmarajan V., Vought V.E., Cosgrove M.S.J. Biol. Chem. 284:24242-24256(2009)

References:

appl_detail:

Predicted MW: 65 80kd
Western blotting: 1:500~1:1000

Datasheet PDF