Product Datasheet  
ASH2L Antibody  
Catalog Number: 21497  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9UBL3
    NCBI Protein: NP_004665.2
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.620~624(G-R-R-S-P) derived from Human ASH2L.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 65 80kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • ASH2; Bre2; ASH2L1; ASH2L2;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total ASH2L protein.
  • Applications：  
  • WB
  • Background：  
  • Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.

    Wysocka J., Myers M.P., Laherty C.D., Eisenman R.N., Herr W.Genes Dev. 17:896-911(2003)
    Patel A., Dharmarajan V., Vought V.E., Cosgrove M.S.J. Biol. Chem. 284:24242-24256(2009)



 
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