E-Cadherin(CD324) Antibody

Catalog Number:

21473

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P12830
NCBI Protein: NP_004351.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.864~868(E-W-G-N-R) derived from Human E-Cadherin.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total E-Cadherin protein.

Applications:

WB

Background:

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin a-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Baki L.et.al(2001)Proc. Natl. Acad. Sci. U.S.A. 98:2381-2386
Makagiansar I.T.et.al(2002)J. Biol. Chem. 277:16002-16010
Agiostratidou G. (2006)J. Neurochem. 96:1182-1188

References:

appl_detail:

Predicted MW: 135kd
Western blotting: 1:500~1:1000

Datasheet PDF