Product Datasheet  
E-Cadherin(CD324) Antibody  
Catalog Number: 21473  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P12830
    NCBI Protein: NP_004351.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.864~868(E-W-G-N-R) derived from Human E-Cadherin.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 135kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • CDH1; CDHE; UVO
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total E-Cadherin protein.
  • Applications：  
  • WB
  • Background：  
  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin a-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

    Baki L.et.al(2001)Proc. Natl. Acad. Sci. U.S.A. 98:2381-2386
    Makagiansar I.T.et.al(2002)J. Biol. Chem. 277:16002-16010
    Agiostratidou G. (2006)J. Neurochem. 96:1182-1188



 
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