CPI17a(Ab-38) Antibody

Catalog Number:

21281

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q96A00
NCBI Protein: NP_150281.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.36~40 (R-V-T-V-K) derived from Human CPI17a.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total CPI17a protein.

Applications:

IF

Background:

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

Hagerty L, et al. (2007) J Biol Chem. 2007; 282(7):4884-93
Seok YM, et al. (2008) J Pharmacol Exp Ther.
Niiro N et al. (2003) Biochem J. 2003 ;369(Pt 1):117-28

References:

appl_detail:

Predicted MW: 17kd
Immunofluorescence: 1:100~1:200

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