Product Datasheet  
CPI17a(Ab-38) Antibody  
Catalog Number: 21281  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q96A00
    NCBI Protein: NP_150281.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.36~40 (R-V-T-V-K) derived from Human CPI17a.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 17kd
    Immunofluorescence: 1:100~1:200
  • other_names：  
  • CPI; CPI-17; CPI17; PP14A;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total CPI17a protein.
  • Applications：  
  • IF
  • Background：  
  • Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

    Hagerty L, et al. (2007) J Biol Chem. 2007; 282(7):4884-93
    Seok YM, et al. (2008) J Pharmacol Exp Ther.
    Niiro N et al. (2003) Biochem J. 2003 ;369(Pt 1):117-28



 
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