PDGF Receptor b(Ab-751) Antibody

Catalog Number:

21219

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P09619
NCBI Protein: NP_002600.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.749~753 (V-D-Y-V-P) derived from Human PDGFRb.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total PDGF Receptor b protein.

Applications:

WB

Background:

PDGF Receptor b encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor a and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Lederle W, et al. (2006) Am J Pathol ; 169(5): 1767-1783.
Vignais ML, et al. (1999) Mol Cell Biol; 19(5): 3727-3735.
Herrlich A, et al. (1998) Proc Natl Acad Sci U S A; 95(15): 8985-8990.
Heuchel R, et al. (1999) Proc Natl Acad Sci U S A; 96(20): 11410-11415.

References:

appl_detail:

Predicted MW: 190kd
Western blotting: 1:500~1:1000

Datasheet PDF