Product Datasheet  
PDGF Receptor b(Ab-751) Antibody  
Catalog Number: 21219  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P09619
    NCBI Protein: NP_002600.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.749~753 (V-D-Y-V-P) derived from Human PDGFRb.
  • reactivity：  
  • Hu Rt
  • appl_detail：  

  • Predicted MW: 190kd
    Western blotting: 1:500~1:1000

  • other_names：  
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total PDGF Receptor b protein.
  • Applications：  
  • WB
  • Background：  

  • PDGF Receptor b encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor a and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

    Lederle W, et al. (2006) Am J Pathol ; 169(5): 1767-1783.
    Vignais ML, et al. (1999) Mol Cell Biol; 19(5): 3727-3735.
    Herrlich A, et al. (1998) Proc Natl Acad Sci U S A; 95(15): 8985-8990.
    Heuchel R, et al. (1999) Proc Natl Acad Sci U S A; 96(20): 11410-11415.




 
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