Ezrin(Ab-353) Antibody

Catalog Number:

21094

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P15311
NCBI Protein: NP_001104547.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.351~355 (Q-D-Y-E-E) derived from Human EZRIN.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total Ezrin protein.

Applications:

WB

Background:

Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

Zhao H, et al. (2004) Proc Natl Acad Sci U S A101 (25): 9485-90.
Wang Q, et al. (2003) J Biol Chem 278(48): 47731-43.
Gautreau A, et al. (1999) Proc Natl Acad Sci U S A: 96(13): 7300-5.
Crepaldi T, et al. (1997) J Cell Biol: 28; 138(2): 423-34.

References:

appl_detail:

Predicted MW: 81kd
Western blotting: 1:500~1:1000

Datasheet PDF