STAT3(Ab-705) Antibody

Catalog Number:

21045

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P40763
NCBI Protein: NP_003141.2

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.703~707(A-P-Y-L-K) derived from Human STAT3.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total STAT3 protein.

Applications:

WB IHC IF

Background:

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

Heim M H, (1999) J Recept Signal Transduct Res. 19: 75-120.
Takeda K, et al. (1997) Proc Natl Acad Sci USA. 94: 3801-3804.
Catlett-Falcone R, et al. (1999) Immunity. 10: 105-115.
Garcia R, et al. (1998) J Biomed Sci. 5: 79-85.
Bromberg J F, et al. (1999) Cell. 98: 295-303.

References:

appl_detail:

Predicted MW: 88kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: IF:1:100~1:200

Datasheet PDF