TRPC6 Antibody

Catalog Number:

21403

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q61143
NCBI Protein: NP_004612.2

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

peptide Corresponding to the amino terminal sequence derived from mouse TRPC6.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Applications:

WB

Background:

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).

Koichiro Kuwahara et al. (2006) J Clin Invest. 116(12): 3114

References:

appl_detail:

Predicted MW: 100kd
Western blotting: 1:500~1:1000

Datasheet PDF