PRL-3 Antibody

Catalog Number:

21333

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O75365
NCBI Protein: NP_116000

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa. 161-166 (K-D-P-H-T) derived from Human PTP4A3.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects transfected PRL-3 protein.

Applications:

WB

Background:

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.

Matter W.F. et.al. Biochem. Biophys. Res. Commun. 283:1061-1068(2001)
Wang J.et.al. J. Biol. Chem. 277:46659-46668(2002)

References:

appl_detail:

Predicted MW: 22kd
Western blotting: 1:500~1:1000

Datasheet PDF