Product Datasheet  
PRL-3 Antibody  
Catalog Number: 21333  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: O75365
    NCBI Protein: NP_116000
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa. 161-166 (K-D-P-H-T) derived from Human PTP4A3.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 22kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • protein tyrosine phosphatase type IVA; PRL3; PRL-R; PTP4A3;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects transfected PRL-3 protein.
  • Applications：  
  • WB
  • Background：  
  • Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.

    Matter W.F. et.al. Biochem. Biophys. Res. Commun. 283:1061-1068(2001)
    Wang J.et.al. J. Biol. Chem. 277:46659-46668(2002)




 
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