AhR (Phospho-Ser36) Antibody

Catalog Number:

12072

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P35869/A9YTQ3;
NCBI Gene#: 196/57491;
NCBI Protein#: NP_001612.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Serine 36 (N-P-S(p)-K-R) derived from Human AhR.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous level of AhR only when phosphorylated at Serine 36.

Applications:

WB

Background:

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.

References:

appl_detail:

Predicted MW: 90kd
Western blotting: 1:500~1:1000

Datasheet PDF