IL-8R beta/CDw128 beta (Phospho-Ser347) Antibody

Catalog Number:

12051

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P25025;
NCBI Gene#: 3579;
NCBI Protein#: NP_001161770.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Serine 347 (R-P-S(p)-F-V) derived from Human IL-8R beta/CDw128 beta

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous level of IL-8R beta/CDw128 beta only when phosphorylated at Serine 347.

Applications:

WB

Background:

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

References:

appl_detail:

Predicted MW: 48kd
Western blotting: 1:500~1:1000

Datasheet PDF