Ataxin 1 (Phospho-Ser776) Antibody

Catalog Number:

12034

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P54253;
NCBI Gene#: 6310;
NCBI Protein#: NP_000323.2

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Serine 776 (R-W-S(p)-A-P) derived from Human Ataxin 1.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous level of Ataxin 1 only when phosphorylated at Serine 776.

Applications:

WB

Background:

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.

References:

appl_detail:

Predicted MW: 87kd
Western blotting: 1:500~1:1000

Datasheet PDF