Product Datasheet  
Ataxin 1 (Phospho-Ser776) Antibody  
Catalog Number: 12034  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P54253;
    NCBI Gene#: 6310;
    NCBI Protein#: NP_000323.2
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Serine 776 (R-W-S(p)-A-P) derived from Human Ataxin 1.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Predicted MW: 87kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • ATX1, D6S504E, SCA1
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of Ataxin 1 only when phosphorylated at Serine 776.
  • Applications：  
  • WB
  • Background：  
  • Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.



 
© Signalway Biotechnology All Rights Reserved.