Estrogen Receptor- beta (Phospho-Ser105) Antibody

Catalog Number:

11998

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q92731;
NCBI Gene#: 2100;
NCBI Protein#: NP_001035365.1

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of serine105(Q-R-S(p)-P-W) derived from Human Estrogen Receptor- beta.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous level of Estrogen Receptor- beta only when phosphorylated at serine 105.

Applications:

WB

Background:

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Hamilton-Burke W, et al. (2010)Am J Pathol 177, 1079-86. St-Laurent V, Sanchez M, Charbonneau C, Tremblay A (2005) J Steroid Biochem Mol Biol 94, 23-37. Tremblay A, Tremblay GB, Labrie F, Gigu¨¨re V (1999) Mol Cell 3, 513-9 .

References:

appl_detail:

Western blotting: 1:500~1:1000

Datasheet PDF