Kv2.1 (Phospho-Ser805) Antibody

Catalog Number:

11923

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q14721;
NCBI Gene#: 2745;
NCBI Protein#: NP_004966.1

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of serine805(P-T-S(p)-P-K) derived from Human Kv2.1 .

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous level of Kv2.1 only when phosphorylated at serine 805.

Applications:

WB

Background:

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.

McCord MC, Aizenman E (2013)Proc Natl Acad Sci U S A 110, 13988-93 . Norris CA, et al. (2012) J Neurosci 32, 8865-70 . Cerda O, Trimmer JS (2011)J Biol Chem 286, 28738-48 .

References:

appl_detail:

Western blotting: 1:500~1:1000

Datasheet PDF