HER2 (Phospho-Tyr1112) Antibody

Catalog Number:

11903

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P04626;
NCBI Gene#: 2064;
NCBI Protein#: NP_001005862.1

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 1112 (Q-R-Y(p)-S-E) derived from Human HER2.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous level of HER2 only when phosphorylated at tyrosine 1112.

Applications:

WB

Background:

Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.

Chuang TD, et al. (2010)J Biol Chem 285, 23598-606
Bhuvaneswari R, Gan YY, Soo KC, Olivo M (2009) Mol Cancer 8, 94
Thelemann A, et al. (2005) Mol Cell Proteomics 4, 356-76

References:

appl_detail:

Western blotting: 1:500~1:1000

Datasheet PDF