Product Datasheet  
HER2 (Phospho-Tyr1112) Antibody  
Catalog Number: 11903  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P04626;
    NCBI Gene#: 2064;
    NCBI Protein#: NP_001005862.1
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of tyrosine 1112 (Q-R-Y(p)-S-E) derived from Human HER2.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:1000
  • other_names：  
  • C-erbB-2; NGL; NEU proto-oncogene; MLN 19;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of HER2 only when phosphorylated at tyrosine 1112.
  • Applications：  
  • WB
  • Background：  

  • Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.

    Chuang TD, et al. (2010)J Biol Chem 285, 23598-606
    Bhuvaneswari R, Gan YY, Soo KC, Olivo M (2009) Mol Cancer 8, 94
    Thelemann A, et al. (2005) Mol Cell Proteomics 4, 356-76




 
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