ITGB1 (Phospho-Tyr795) Antibody

Catalog Number:

11824

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P05556;
NCBI Gene#: 3688;
NCBI Protein#: NP_002202.2.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 795(P-K-Y(p)-E-G) derived from Human ITGB1 .

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of ITGB1 only when phosphorylated at tyrosine 795.

Applications:

WB

Background:

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.

Argraves W.S., J. Cell Biol. 105:1183-1190(1987).
Ota T., Nat. Genet. 36:40-45(2004).
Bechtel S., BMC Genomics 8:399-399(2007).

References:

appl_detail:

Western blotting: 1:500~1:1000

Datasheet PDF