HS1 (Phospho-Tyr397) Antibody

Catalog Number:

11817

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P14317;
NCBI Gene#: 3059;
NCBI Protein#: NP_005326.2.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 397(G-D-Y(p)-E-E) derived from Human HS1 .

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of HS1 only when phosphorylated at tyrosine 397.

Applications:

WB

Background:

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. Directly associates with HAX-1, through binding to its C-terminal region. May also be involved in the regulation of gene expression.

Kitamura D., Nucleic Acids Res. 17:9367-9379(1989).
Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T., Nat. Genet. 36:40-45(2004).

References:

appl_detail:

Western blotting: 1:500~1:1000

Datasheet PDF