Product Datasheet  
HS1 (Phospho-Tyr397) Antibody  
Catalog Number: 11817  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P14317;
    NCBI Gene#: 3059;
    NCBI Protein#: NP_005326.2.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of tyrosine 397(G-D-Y(p)-E-E) derived from Human HS1 .
  • reactivity：  
  • Hu
  • appl_detail：  

  • Western blotting: 1:500~1:1000

  • other_names：  
  • HCLS1; LCKBP1; Hematopoietic cell- specific LYN substrate 1;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of HS1 only when phosphorylated at tyrosine 397.
  • Applications：  
  • WB
  • Background：  

  • Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. Directly associates with HAX-1, through binding to its C-terminal region. May also be involved in the regulation of gene expression.

    Kitamura D., Nucleic Acids Res. 17:9367-9379(1989).
    Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
    Ota T., Nat. Genet. 36:40-45(2004).




 
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