MEF2C (Phospho-Ser396) Antibody

Catalog Number:

11808

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q06413;
NCBI Gene#: 4208;
NCBI Protein#: NP_001180279.1.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Serine 396(P-V-S(p)-P-P) derived from Human MEF2C.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of MEF2C only when phosphorylated at serine 396.

Applications:

WB IHC

Background:

MEF2C transcription factor of the MADS family which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in myogenesis, neurogenesis and in the development of cortical architecture. Three splice-variant isoforms have been described.

Leifer D., Proc. Natl. Acad. Sci. U.S.A. 90:1546-1550(1993).
McDermott J.C., Mol. Cell. Biol. 13:2564-2577(1993).
Wang A.H., Mol. Cell. Biol. 19:7816-7827(1999).

References:

appl_detail:

Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100

Datasheet PDF